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MicroRNAs are critical in regulating smooth muscle cell mineralization and apoptosis during vascular calcification
- Source :
- Journal of Cellular and Molecular Medicine
- Publication Year :
- 2020
-
Abstract
- Vascular calcification refers to the pathological deposition of calcium and phosphate minerals into the vasculature. It is prevalent in atherosclerosis, ageing, type 2 diabetes mellitus and chronic kidney disease, thus, increasing morbidity and mortality from these conditions. Vascular calcification shares similar mechanisms with bone mineralization, with smooth muscle cells playing a critical role in both processes. In the last decade, a variety of microRNAs have been identified as key regulators for the differentiation, phenotypic switch, proliferation, apoptosis, cytokine production and matrix deposition in vascular smooth muscle cells during vascular calcification. Therefore, this review mainly discusses the roles of microRNAs in the pathophysiological mechanisms of vascular calcification in smooth muscle cells and describes several interventions against vascular calcification by regulating microRNAs. As the exact mechanisms of calcification remain not fully elucidated, having a better understanding of microRNA involvement in vascular calcification may give impetus to development of novel therapeutics for the control and treatment of vascular calcification.
- Subjects :
- 0301 basic medicine
Vascular smooth muscle
transdifferentiation
medicine.medical_treatment
Cell
Myocytes, Smooth Muscle
Reviews
Review
Muscle, Smooth, Vascular
03 medical and health sciences
0302 clinical medicine
Osteogenesis
microRNA
medicine
Animals
Humans
business.industry
Transdifferentiation
apoptosis
Disease Management
Cell Biology
medicine.disease
Pathophysiology
microRNAs
smooth muscle cells
030104 developmental biology
medicine.anatomical_structure
Cytokine
Gene Expression Regulation
Apoptosis
vascular calcification
030220 oncology & carcinogenesis
Cell Transdifferentiation
Cancer research
Molecular Medicine
RNA Interference
Disease Susceptibility
business
Biomarkers
Calcification
Signal Transduction
Subjects
Details
- ISSN :
- 15824934
- Volume :
- 24
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of cellular and molecular medicine
- Accession number :
- edsair.doi.dedup.....b245b544bba7ffdb6ac11a436561c761