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Clinical implications of shared genetics and pathogenesis in autoimmune diseases
- Source :
- Nature Reviews Endocrinology
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Many endocrine diseases, including type 1 diabetes mellitus, Graves disease, Addison disease and Hashimoto disease, originate as an autoimmune reaction that affects disease-specific target organs. These autoimmune diseases are characterized by the development of specific autoantibodies and by the presence of autoreactive T cells. They are caused by a complex genetic predisposition that is attributable to multiple genetic variants, each with a moderate-to-low effect size. Most of the genetic variants associated with a particular autoimmune endocrine disease are shared between other systemic and organ-specific autoimmune and inflammatory diseases, such as rheumatoid arthritis, coeliac disease, systemic lupus erythematosus and psoriasis. Here, we review the shared and specific genetic background of autoimmune diseases, summarize their treatment options and discuss how identifying the genetic and environmental factors that predispose patients to an autoimmune disease can help in the diagnosis and monitoring of patients, as well as the design of new treatments.
- Subjects :
- Endocrinology, Diabetes and Metabolism
NF-KAPPA-B
Genome-wide association study
VOLATILE ORGANIC-COMPOUNDS
ADDISONS-DISEASE
Coeliac disease
Autoimmune Diseases
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Endocrinology
Genetic predisposition
Humans
Lupus Erythematosus, Systemic
Medicine
Genetic Predisposition to Disease
JAPANESE POPULATION
Hashimoto Disease
SYSTEMIC-LUPUS-ERYTHEMATOSUS
GENOME-WIDE ASSOCIATION
030304 developmental biology
Autoimmune disease
0303 health sciences
Lupus erythematosus
business.industry
Autoantibody
CELIAC-DISEASE
Microchimerism
medicine.disease
RHEUMATOID-ARTHRITIS
3. Good health
030220 oncology & carcinogenesis
Immunology
PSORIASIS SUSCEPTIBILITY LOCI
business
INFLAMMATORY-BOWEL-DISEASE
Subjects
Details
- ISSN :
- 17595037 and 17595029
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Endocrinology
- Accession number :
- edsair.doi.dedup.....b2435ae29d1fd77c237e7087ff80bf2e