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Characteristics, clinical outcomes, and risk factors of SARS-COV-2 infection in adult acute myeloid leukemia patients: experience of the PETHEMA group
- Source :
- Leukemia & lymphoma, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, LEUKEMIA & LYMPHOMA, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
- Publication Year :
- 2021
- Publisher :
- TAYLOR & FRANCIS LTD, 2021.
-
Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces higher morbidity and mortality in hematological malignancies, but evidence in acute myeloid leukemia (AML) is scarce. A multicenter observational study was conducted to determine the clinical outcomes and assess the impact of therapeutic approaches in adult AML patients with SARS-CoV-2 infection in the first wave (March-May 2020). Overall, 108 patients were included: 51.9% with active leukemia and 70.4% under therapeutic schedules for AML. Signs and symptoms of SARS-CoV-2 were present in 96.3% of patients and 82.4% received specific treatment for SARS-CoV-2. The mortality rate was 43.5% and was correlated with age, gender, active leukemia, dyspnea, severe SARS-CoV-2, intensive care measures, neutrophil count, and D-dimer levels. A protective effect was found with azithromycin, lopinavir/ritonavir, and normal liver enzyme levels. During the SARS-CoV-2 first wave, our findings suggested an increased mortality in AML in a short period. SARS-CoV-2 management could be guided by risk factors in AML patients.
- Subjects :
- Cancer Research
medicine.medical_specialty
viruses
acute myeloid leukemia
COVID-19, SARS-CoV-2, acute myeloid leukemia, hematological malignancies
Intensive care
Internal medicine
hemic and lymphatic diseases
medicine
hematological malignancies
skin and connective tissue diseases
business.industry
SARS-CoV-2
Mortality rate
Myeloid leukemia
COVID-19
virus diseases
Lopinavir
Adult Acute Myeloid Leukemia
Hematology
medicine.disease
body regions
Leukemia
Oncology
Absolute neutrophil count
Ritonavir
business
medicine.drug
Subjects
Details
- ISSN :
- 10428194
- Database :
- OpenAIRE
- Journal :
- Leukemia & lymphoma, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, LEUKEMIA & LYMPHOMA, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
- Accession number :
- edsair.doi.dedup.....b2213676a4f3ebf8d1e2cd0a70b6679f