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Design and Synthesis of Anti-Cancer Chimera Molecules Based on Marine Natural Products
- Source :
- Marine Drugs, Marine Drugs, Vol 17, Iss 9, p 500 (2019)
- Publication Year :
- 2019
-
Abstract
- In this paper, the chemical conjugation of marine natural products with other bioactive molecules for developing an advanced anti-cancer agent is described. Structural complexity and the extraordinary biological features of marine natural products have led to tremendous research in isolation, structural elucidation, synthesis, and pharmacological evaluation. In addition, this basic scientific achievement has made it possible to hybridize two or more biologically important skeletons into a single compound. The hybridization strategy has been used to identify further opportunities to overcome certain limitations, such as structural complexity, scarcity problems, poor solubility, severe toxicity, and weak potency of marine natural products for advanced development in drug discovery. Further, well-designed marine chimera molecules can function as a platform for target discovery or degradation. In this review, the design, synthesis, and biological evaluation of recent marine chimera molecules are presented.
- Subjects :
- Aquatic Organisms
chemical conjugation
Bioactive molecules
Drug Evaluation, Preclinical
Pharmaceutical Science
Antineoplastic Agents
Computational biology
Chemistry Techniques, Synthetic
Review
01 natural sciences
chimera
03 medical and health sciences
Chimera (genetics)
Neoplasms
Drug Discovery
Molecule
Humans
lcsh:QH301-705.5
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Severe toxicity
hybridization
030304 developmental biology
Biological evaluation
0303 health sciences
Biological Products
Molecular Structure
010405 organic chemistry
Chemistry
Drug discovery
marine natural products
Chemical conjugation
0104 chemical sciences
anticancer agent
lcsh:Biology (General)
Solubility
Drug Design
Scientific achievement
Subjects
Details
- ISSN :
- 16603397
- Volume :
- 17
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Marine drugs
- Accession number :
- edsair.doi.dedup.....b221338d6c28e1d99bf3e377d2d80dcc