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Etodolac Attenuates Mechanical Allodynia in a Mouse Model of Neuropathic Pain
- Source :
- Journal of Pharmacological Sciences, Vol 109, Iss 4, Pp 600-605 (2009)
- Publication Year :
- 2009
- Publisher :
- Elsevier, 2009.
-
Abstract
- Cyclooxygenase (COX) contributes to neuropathic pain after peripheral nerve injury, yet COX inhibitors are generally ineffective against mechanical allodynia and hyperalgesia in neuropathic pain patients and animal models. In the present study, we investigated the effects of etodolac, a selective COX-2 inhibitor, on mechanical allodynia in mice after partial sciatic nerve ligation (PSNL) compared to indomethacin (a nonselective COX inhibitor) or celecoxib (a selective COX-2 inhibitor). PSNL decreased the paw-withdrawal threshold (PWT) as assessed by the von Frey hair test, and etodolac, but not indomethacin or celecoxib, administered daily for two weeks, partially or wholly reversed the decrease. The efficacy of etodolac gradually increased throughout the administration period, and the higher dosages restored preligation PWT values by day 21. The positive control pregabalin also partially or wholly reversed the decrease in PWT, but in contrast to etodolac, it showed no increase in efficacy throughout the administration period. In normal mice, etodolac did not affect the PWT, whereas pregabalin increased it. These findings suggest that the mechanisms of inhibition of mechanical allodynia by etodolac and pregabalin are different and demonstrate that in contrast to other COX inhibitors, etodolac is effective against mechanical allodynia in a mouse neuropathic pain model. Keywords:: etodolac, neuropathic pain, cyclooxygenase (COX)-2, partial sciatic nerve ligation, mechanical allodynia
- Subjects :
- Male
Pregabalin
Pain
Carrageenan
Mice
medicine
Animals
Edema
Etodolac
Ligation
gamma-Aminobutyric Acid
Pain Measurement
Pharmacology
Sulfonamides
Cyclooxygenase 2 Inhibitors
biology
business.industry
Anti-Inflammatory Agents, Non-Steroidal
lcsh:RM1-950
lcsh:Therapeutics. Pharmacology
Celecoxib
Anesthesia
Hyperalgesia
Peripheral nerve injury
Neuropathic pain
biology.protein
Pyrazoles
Molecular Medicine
Indicators and Reagents
Sciatic nerve
Cyclooxygenase
Sciatic Neuropathy
medicine.symptom
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 13478613
- Volume :
- 109
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....b21f7ec966174fbc61db5804bdaad45e