Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates

Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II , 12.2% had aac(6 ′ )-Ib/Ib-cr , and 5.4% had the methylase genes ( rmtB , armA ). Aminoglycoside-resistant isolates with aac( ′ )-Ib/Ib-cr , rmtB , and armA often had coresistance to multiple other antibiotics.