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Central nervous system hemangioblastomas: An age-stratified analysis
- Source :
- Clinical Neurology and Neurosurgery. 199:106281
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background Hemangioblastomas (HBs) are rare and understudied. The impact of age on clinical features, optimal treatment, and postoperative outcome in HBs has not been systemically studied. Materials and Methods We performed an institutional study in the West China Hospital, including patients diagnosed with hemangioblastomas between October 2011 and October 2016. Clinical data and surgical outcomes were compared among three different age groups (0−20, 21−59, and ≥ 60 years). We also studied surgical prognostic factors. Results 187 patients (102 males and 85 females) were identified. HBs in spinal locations were more prevalent in children and adolescents, while the most common site in young and old-age adults was the cerebellum (P = 0.023). Risk of Von Hippel–Lindau syndrome (VHL) was negatively correlated with patient age (P = 0.003). 47.6 % of patients aged 0−20, 23 % of patients aged 21−59, and 6.45 % of patients aged ≥60 years were diagnosed with VHL. Older aged patients had a significantly lower risk of VHL and had a lower tumor recurrence rate. Surgical resection was an adequate and sufficient procedure in all age groups with a favorable surgical outcome (P = 0.823). Solid tumor, VHL disease, and localization in the brainstem were associated with poor outcome in patients with hemangioblastomas. Conclusions Our study showed that HBs in elderly patients were mostly included in the cerebellum and had a solid configuration and large size, while HBs in children were mainly localized in the spinal cord. VHL disease was more common in children and adolescents but rare in patients older than 60 years. The present study found no excess surgical mortality and risks for HBs in elderly patients or children than in younger adults.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Central nervous system
Disease
Lower risk
Stratified analysis
Young Adult
03 medical and health sciences
0302 clinical medicine
Patient age
medicine
Humans
Postoperative outcome
In patient
Spinal Cord Neoplasms
Cerebellar Neoplasms
Child
Aged
business.industry
Age Factors
Infant, Newborn
Surgical mortality
Infant
General Medicine
Middle Aged
Hemangioblastoma
medicine.anatomical_structure
Child, Preschool
030220 oncology & carcinogenesis
Female
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 03038467
- Volume :
- 199
- Database :
- OpenAIRE
- Journal :
- Clinical Neurology and Neurosurgery
- Accession number :
- edsair.doi.dedup.....b2107d589e85fd5e1b6159f01d822878