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19F NMR as a tool in chemical biology
- Source :
- Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 293-318 (2021), Beilstein Journal of Organic Chemistry
- Publication Year :
- 2021
- Publisher :
- Beilstein-Institut, 2021.
-
Abstract
- We previously reviewed the use of 19F NMR in the broad field of chemical biology [Cobb, S. L.; Murphy, C. D. J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the literature from the last decade that has the technique as the central method of analysis. The topics covered include the synthesis of new fluorinated probes and their incorporation into macromolecules, the application of 19F NMR to monitor protein–protein interactions, protein–ligand interactions, physiologically relevant ions and in the structural analysis of proteins and nucleic acids. The continued relevance of the technique to investigate biosynthesis and biodegradation of fluorinated organic compounds is also described.
- Subjects :
- 010405 organic chemistry
Chemistry
Organic Chemistry
Chemical biology
chemical biology
Method of analysis
Fluorine-19 NMR
Review
010402 general chemistry
01 natural sciences
0104 chemical sciences
lcsh:QD241-441
Protein structure
lcsh:Organic chemistry
Computational chemistry
fluorine
Nucleic acid
lcsh:Q
biotransformation
protein structure
probes
lcsh:Science
19f nmr
Macromolecule
Subjects
Details
- Language :
- English
- ISSN :
- 18605397
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Beilstein Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....b20be9a1c41d1893ffae76793ceaa156