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Artificial Natural Killer Cells for Specific Tumor Inhibition and Renegade Macrophage Re-Education
- Source :
- Advanced materials (Deerfield Beach, Fla.). 31(43)
- Publication Year :
- 2019
-
Abstract
- Natural killer (NK) cells can not only recognize and eliminate abnormal cells but also recruit and re-educate immune cells to protect the host. However, the functions of NK cells are often limited in the immunosuppressive tumor microenvironment (TME). Here, artificial NK cells (designated as aNK) with minor limitations of TME for specific tumor killing and renegade macrophage re-education are created. The red blood cell membrane (RBCM) cloaks perfluorohexane (PFC) and glucose oxidase (GOX) to construct the aNK. The aNK can directly kill tumor cells by exhausting glucose and generating hydrogen peroxide (H2 O2 ). The generated H2 O2 is also similar to cytokines and chemokines for recruiting immune cells and re-educating survived macrophages to attack tumor cells. In addition, the oxygen-carried PFC can strengthen the catalytic reaction of GOX and normalize the hypoxic TME. In vitro and in vivo experiments display that aNK with slight TME limitations exhibit efficient tumor inhibition and immune activation. The aNK will provide a new sight to treat tumor as the supplement of aggressive NK cells.
- Subjects :
- Chemokine
Materials science
medicine.medical_treatment
02 engineering and technology
010402 general chemistry
01 natural sciences
Glucose Oxidase
Mice
Immune system
In vivo
Biomimetics
Cell Line, Tumor
medicine
Tumor Microenvironment
Macrophage
Animals
General Materials Science
Tumor microenvironment
biology
Mechanical Engineering
Macrophages
Immunotherapy
Hydrogen Peroxide
021001 nanoscience & nanotechnology
In vitro
0104 chemical sciences
Killer Cells, Natural
Red blood cell
medicine.anatomical_structure
Glucose
Mechanics of Materials
Cancer research
biology.protein
Cytokines
0210 nano-technology
Subjects
Details
- ISSN :
- 15214095
- Volume :
- 31
- Issue :
- 43
- Database :
- OpenAIRE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Accession number :
- edsair.doi.dedup.....b209721005cb6efcc098548ead17efff