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Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells
- Source :
- Nature immunology
- Publication Year :
- 2015
-
Abstract
- The cells that stimulate positive selection express specialized proteasome β-subunits different from those expressed by all other cells, including those involved in negative selection. Mice that lack all four specialized proteasome β-subunits, and therefore express only constitutive proteasomes in all cells, had a profound defect in the generation of CD8(+) T cells. While a defect in positive selection would reflect an inability to generate the appropriate positively selecting peptides, a block at negative selection would point to the potential need to switch peptides between positive selection and negative selection to avoid the two processes' often cancelling each other out. We found that the block in T cell development occurred around the checkpoints of positive selection and, unexpectedly, negative selection as well.
- Subjects :
- 0301 basic medicine
Male
Proteasome Endopeptidase Complex
Cellular differentiation
T cell
Immunology
Antigen presentation
Thymus Gland
Biology
CD8-Positive T-Lymphocytes
Article
03 medical and health sciences
Negative selection
Mice
mental disorders
medicine
Immunology and Allergy
Cytotoxic T cell
Humans
Animals
Clonal Selection, Antigen-Mediated
Selection (genetic algorithm)
Cells, Cultured
Genetics
Mice, Knockout
Antigen Presentation
Histocompatibility Antigens Class I
Cell Differentiation
Mice, Inbred C57BL
Cysteine Endopeptidases
030104 developmental biology
medicine.anatomical_structure
Proteasome
Female
Peptides
CD8
Subjects
Details
- ISSN :
- 15292916
- Volume :
- 17
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Nature immunology
- Accession number :
- edsair.doi.dedup.....b1fe9bedf4b4919d8924f5a221c862e1