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miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes
- Source :
- Journal of Endocrinological Investigation, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Purpose Type 2 diabetes frequently remains undiagnosed for years, whereas early detection of affected individuals would facilitate the implementation of timely and cost-effective therapies, hence decreasing morbidity. With the intention of identifying novel diagnostic biomarkers, we characterized the miRNA profile of microvesicles isolated from retroactive serum samples of normoglycemic individuals and two groups of subjects with prediabetes that in the following 4 years either progressed to overt diabetes or remained stable. Methods We profiled miRNAs in serum microvesicles of a selected group of control and prediabetic individuals participating in the PREDAPS cohort study. Half of the subjects with prediabetes were diagnosed with diabetes during the 4 years of follow-up, while the glycemic status of the other half remained unchanged. Results We identified two miRNAs, miR-10b and miR-223-3p, which target components of the insulin signaling pathway and whose ratio discriminates between these two subgroups of prediabetic individuals at a stage at which other features, including glycemia, are less proficient at separating them. In global, the profile of miRNAs in microvesicles of prediabetic subjects primed to progress to overt diabetes was more similar to that of diabetic patients than the profile of prediabetic subjects who did not progress. Conclusion We have identified a miRNA signature in serum microvesicles that can be used as a new screening biomarker to identify subjects with prediabetes at high risk of developing diabetes, hence allowing the implementation of earlier, and probably more effective, therapeutic interventions.
- Subjects :
- Blood Glucose
Oncology
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
Prediabetic State
03 medical and health sciences
0302 clinical medicine
Endocrinology
Microvesicle
mir-223
Cell-Derived Microparticles
Diabetes mellitus
Internal medicine
Diagnosis
medicine
Humans
Prediabetes
Aged
Glycemic
Progression
business.industry
MicroRNA
Biomarker
Middle Aged
medicine.disease
Microvesicles
MicroRNAs
Diabetes Mellitus, Type 2
030220 oncology & carcinogenesis
Disease Progression
Biomarker (medicine)
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 17208386
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi.dedup.....b1fa5730f4c3b6f0884a0da55aae4885