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Longitudinal clinical, cognitive, and neuroanatomical changes over 5 years in GBA-positive Parkinson's disease patients
- Source :
- Journal of neurology. 269(3)
- Publication Year :
- 2021
-
Abstract
- Objective: To study the longitudinal disease course of Parkinson’s disease (PD) patients with glucocerebrosidase (GBA) mutation (GBA-positive) compared to PD non-carriers (GBA-negative) along a 5-year follow-up, evaluating changes in clinical and cognitive outcomes, cortical thickness, and gray-matter (GM) volumes. Methods: Ten GBA-positive and 20 GBA-negative PD patients underwent clinical, neuropsychological, and MRI assessments (cortical thickness and subcortical, hippocampal, and amygdala volumes) at study entry and once a year for 5 years. At baseline and at the last visit, each group of patients was compared with 22 age-matched healthy controls. Clinical, cognitive, and MRI features were compared between groups at baseline and over time. Results: At baseline, GBA-positive and GBA-negative PD patients had similar clinical and cognitive profiles. Compared to GBA-negative and controls, GBA-positive patients showed cortical thinning of left temporal, parietal, and occipital gyri. Over time, compared to GBA-negative, GBA-positive PD patients progressed significantly in motor and cognitive symptoms, and showed a greater pattern of cortical thinning of posterior regions, and frontal and orbito-frontal cortices. After 5 years, compared to controls, GBA-negative PD patients showed a pattern of cortical thinning similar to that showed by GBA-positive cases at baseline. The two groups of patients showed similar patterns of subcortical, hippocampal, and amygdala volume loss over time. Conclusions: Compared to GBA-negative PD, GBA-positive patients experienced a more rapid motor and cognitive decline together with a greater, earlier and faster cortical thinning. Cortical thickness measures may be a useful tool for monitoring and predicting PD progression in accordance with the genetic background.
- Subjects :
- medicine.medical_specialty
Neurology
Parkinson's disease
Amygdala
Cortical thickness
03 medical and health sciences
0302 clinical medicine
Magnetic resonance imaging
Cognition
Glucocerebrosidase gene
Internal medicine
medicine
Humans
Cognitive Dysfunction
Cognitive decline
Gray Matter
030304 developmental biology
Neuroradiology
0303 health sciences
medicine.diagnostic_test
business.industry
Neuropsychology
Parkinson Disease
medicine.disease
medicine.anatomical_structure
Mutation
Cardiology
Parkinson’s disease
Glucosylceramidase
GBA
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14321459
- Volume :
- 269
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neurology
- Accession number :
- edsair.doi.dedup.....b1f5cafb0cc8409df78f2e83ba66181b