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Opto-chemical treatment for enhanced high-level disinfection of mature bacterial biofilm in a Teflon-based endoscope model
- Source :
- Biomed Opt Express
- Publication Year :
- 2021
-
Abstract
- Medical societies and public health agencies rigorously emphasize the importance of adequate disinfection of flexible endoscopes. The aim of this work was to propose a novel opto-chemical disinfection treatment against Staphylococcus aureus grown in mature biofilm on Teflon-based endoscope channel models. Laser irradiation using near-infrared and blue wavelengths combined with a low concentration of chemical disinfectant induced both irreversible thermal denaturation and intercellular oxidative stress as a combined mechanism for an augmented antimicrobial effect. The opto-chemical method yielded a 6.7–log10 reduction of the mature Staphylococcus aureus biofilms (i.e., approximately 1.0-log10 higher than current requirement of standard treatment). The proposed technique may be a feasible disinfection method for mitigating the risk associated with infection transmission.
Details
- ISSN :
- 21567085
- Volume :
- 12
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Biomedical optics express
- Accession number :
- edsair.doi.dedup.....b1e147b30a8ba23936cdee636877d180