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Risk of Electrolyte Disorders, Syncope, and Falls in Patients Taking Thiazide Diuretics: Results of a Cross-Sectional Study
- Source :
- The American Journal of Medicine. 134:1148-1154
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background: Thiazide diuretics are a mainstay in the management of hypertension and often associated with dyselectrolytemias. We investigated the prevalence of and risk factors for hyponatremia and hypokalemia in thiazide users, substance-specific differences, and the association of thiazides with syncope and falls. Methods: In this cross-sectional analysis all patients admitted to an interdisciplinary emergency department in Switzerland between January 1, 2017, and December 31, 2018, with measurements of serum sodium and potassium were included. Data regarding serum electrolytes and creatinine were analyzed to classify for dysnatremias, dyskalemias, and acute kidney injury. Chart reviews were performed to screen for syncope or falls. Results: A total of 1604 patients (7.9%) took thiazides. Acute kidney injury was significantly more common in thiazide users (22.1 vs 7%, P < .0001). Hyponatremia (22.1 vs 9.8%, P < .0001) and hypokalemia (19 vs 11%, P < .0001) were more frequent with thiazides. Thiazide use together with higher age and female sex were independent predictors of hyponatremia and hypokalemia. A dose-dependent effect was found for electrolyte disorders, and there was a variance in risk between the investigated substances with chlorthalidone bearing the highest and hydrochlorothiazide the lowest risk. Patients taking thiazide diuretics had significantly more episodes of syncope and falls. Conclusions: Thiazide use is a clear risk factor for hyponatremia and hypokalemia. The effect appears to be dose-dependent and highly variable depending on the substance. Syncope and falls seem to be causally related to thiazide use. Especially in patients who are elderly, female, and prone to falls, the use of thiazide diuretics should be thoroughly questioned.
- Subjects :
- Male
medicine.medical_specialty
Sodium Chloride Symporter Inhibitors
Hypokalemia
030204 cardiovascular system & hematology
Risk Assessment
Syncope
03 medical and health sciences
0302 clinical medicine
Hydrochlorothiazide
Internal medicine
Prevalence
medicine
Humans
030212 general & internal medicine
Risk factor
610 Medicine & health
Antihypertensive Agents
Thiazide
Aged
business.industry
Acute kidney injury
Chlorthalidone
nutritional and metabolic diseases
General Medicine
Middle Aged
Water-Electrolyte Balance
medicine.disease
Cross-Sectional Studies
Hypertension
Accidental Falls
Female
medicine.symptom
Hyponatremia
business
Switzerland
Electrolyte Disorder
medicine.drug
Subjects
Details
- ISSN :
- 00029343
- Volume :
- 134
- Database :
- OpenAIRE
- Journal :
- The American Journal of Medicine
- Accession number :
- edsair.doi.dedup.....b1dd28f54742e69ed7b6e8b4dfa77587