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Potential Roles for G-Quadruplexes in Mitochondria
- Source :
- Current Medicinal Chemistry. 26:2918-2932
- Publication Year :
- 2019
- Publisher :
- Bentham Science Publishers Ltd., 2019.
-
Abstract
- Some DNA or RNA sequences rich in guanine (G) nucleotides can adopt noncanonical conformations known as G-quadruplexes (G4). In the nuclear genome, G4 motifs have been associated with genome instability and gene expression defects, but they are increasingly recognized to be regulatory structures. Recent studies have revealed that G4 structures can form in the mitochondrial genome (mtDNA) and potential G4 forming sequences are associated with the origin of mtDNA deletions. However, little is known about the regulatory role of G4 structures in mitochondria. In this short review, we will explore the potential for G4 structures to regulate mitochondrial function, based on evidence from the nucleus.
- Subjects :
- DNA Replication
Genome instability
Mitochondrial DNA
Nuclear gene
Transcription, Genetic
RNA, Mitochondrial
Mitochondrion
Biology
G-quadruplex
DNA, Mitochondrial
Biochemistry
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
Gene expression
Animals
Humans
030304 developmental biology
Pharmacology
Genetics
0303 health sciences
Organic Chemistry
RNA
Mitochondria
G-Quadruplexes
chemistry
Protein Biosynthesis
Molecular Medicine
030217 neurology & neurosurgery
DNA
Subjects
Details
- ISSN :
- 09298673
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Current Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....b1db7cfc4b6b29a889b36f28388c4a0a