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Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study
- Source :
- The Journal of Headache and Pain, Vol 20, Iss 1, Pp 1-10 (2019), The Journal of Headache and Pain
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Although altered neural networks have been demonstrated in recent MEG (magnetoencephalography) research in migraine patients during resting state, it is unknown whether this alteration can be detected in task-related networks. The present study aimed to investigate the abnormalities of the frequency-specific somatosensory-related network in migraine patients by using MEG. Methods Twenty-two migraineurs in the interictal phase and twenty-two sex- and age-matched healthy volunteers were studied using a whole-head magnetoencephalography (MEG) system. Electrical stimuli were delivered alternately to the median nerve on the right wrists of all subjects. MEG data were analyzed in a frequency range of 1–1000 Hz in multiple bands. Results The brain network patterns revealed that the patients with migraine exhibited remarkably increased functional connectivity in the high-frequency (250–1000 Hz) band between the sensory cortex and the frontal lobe. The results of quantitative analysis of graph theory showed that the patients had (1) an increased degree of connectivity in the theta (4–8 Hz), beta (13–30 Hz) and gamma (30–80 Hz) bands; (2) an increased connectivity strength in the beta (13–30 Hz) and gamma (30–80 Hz) bands; (3) an increased path length in the beta (13–30 Hz), gamma (30–80 Hz) and ripple (80–250 Hz) bands; and (4) an increased clustering coefficient in the theta (4–8 Hz), beta (13–30 Hz) and gamma (30–80 Hz) bands. Conclusions The results indicate that migraine is associated with aberrant connections from the somatosensory cortex to the frontal lobe. The frequency-specific increases in connectivity in terms of strength, path length and clustering coefficients support the notion that migraineurs have elevated cortical networks. This alteration in functional connectivity may be involved in somatosensory processing in migraine patients and may contribute to understanding migraine pathophysiology and to providing convincing evidence for a spatially targeted migraine therapy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neurology
Migraine Disorders
Somatosensory
lcsh:Medicine
Somatosensory system
Young Adult
Functional connectivity
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Ictal
030212 general & internal medicine
Sensory cortex
Migraine
Brain Mapping
Resting state fMRI
medicine.diagnostic_test
Multi-frequency
business.industry
lcsh:R
Brain
Magnetoencephalography
Somatosensory Cortex
General Medicine
medicine.disease
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Frontal lobe
Female
Neurology (clinical)
Nerve Net
business
Neuroscience
030217 neurology & neurosurgery
Research Article
Subjects
Details
- ISSN :
- 11292377 and 11292369
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- The Journal of Headache and Pain
- Accession number :
- edsair.doi.dedup.....b1c61707082aad6aadbac5e18abfdf90