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TWIST1 and SNAI1 as markers of poor prognosis in human colorectal cancer are associated with the expression of ALDH1 and TGF-β1
- Source :
- Oncology reports. 31(3)
- Publication Year :
- 2013
-
Abstract
- Epithelial-mesenchymal transition (EMT) is an important factor in cancer invasiveness and metastatic progression. During EMT, cancer cells acquire stem cell properties. The role of EMT and stemness in colon cancer has not been fully understood. We aimed to demonstrate the clinical significance of EMT and the stem cell phenotype in colorectal cancer. Two hundred and thirty-one surgically resected colon cancer cases were included in the present study. mRNAs of E-cadherin, TWIST1 and SNAI1 were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) (n=109). Immunohistochemical staining was performed for six markers (ALDH1, TGF-β1, E-cadherin, β-catenin, TWSIT1 and SNAI1) (n=231). We assessed clinicopathological characteristics according to the expression of the stem cell phenotype and EMT markers. Based on the results of qRT-PCR, TWIST1 and SNAI1 significantly influenced node metastasis (P=0.04 and P=0.02, respectively). High TWIST1 and SNAI1 mRNA expression was associated with poor overall survival according to the univariate analysis (P
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Epithelial-Mesenchymal Transition
Colorectal cancer
Gene Expression
Kaplan-Meier Estimate
Biology
medicine.disease_cause
Stem cell marker
Aldehyde Dehydrogenase 1 Family
Transforming Growth Factor beta1
Antigens, CD
Internal medicine
medicine
Biomarkers, Tumor
Humans
Epithelial–mesenchymal transition
beta Catenin
Aged
Aged, 80 and over
Twist-Related Protein 1
Cancer
Nuclear Proteins
Retinal Dehydrogenase
General Medicine
Middle Aged
medicine.disease
Cadherins
Prognosis
Adenocarcinoma, Mucinous
Isoenzymes
Lymphatic Metastasis
Cancer cell
Multivariate Analysis
Cancer research
Neoplastic Stem Cells
Adenocarcinoma
Female
Snail Family Transcription Factors
Stem cell
Carcinogenesis
Colorectal Neoplasms
Transcription Factors
Subjects
Details
- ISSN :
- 17912431
- Volume :
- 31
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....b1c479fcd135312ab1d26567ba7f3ea8