Back to Search
Start Over
Allogeneic HSCT for Autoimmune Diseases: A Retrospective Study From the EBMT ADWP, IEWP, and PDWP Working Parties
- Source :
- Frontiers in Immunology, Vol 10 (2019), Frontiers in Immunology, 10
- Publication Year :
- 2019
-
Abstract
- Background: This retrospective study assessed the use and long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with severe autoimmune diseases (ADs), reported to the European Society for Blood and Marrow Transplantation (EBMT) registry. Methods: Between 1997 and 2014, 128 patients received allogeneic HSCT for various hematological (n = 49) and non-hematological (n = 79) refractory ADs. The median age was 12.7 years (0.2-62.2). Donors were syngeneic for seven, matched related for 46, unrelated for 51, haploidentical for 15, and cord blood for nine patients. Results: The incidence of grades II-IV acute graft-vs.-host disease (GvHD) was 20.8% at 100 days. Cumulative incidence of chronic GvHD was 27.8% at 5-years. Non-relapse mortality (NRM) was 12.7% at 100-days. Overall survival (OS) and Progression-Free Survival (PFS) were 70.2 and 59.4% at 5-years, respectively. By multivariate analysis, age
- Subjects :
- 0301 basic medicine
Male
Multivariate analysis
Transplantation Conditioning
medicine.medical_treatment
Autoimmune diseases
hematological autoimmune diseases
Graft vs Host Disease
Hematopoietic stem cell transplantation
Disease
0302 clinical medicine
Immunology and Allergy
Medicine
Cumulative incidence
Child
Incidence (epidemiology)
Incidence
Age Factors
Hematopoietic Stem Cell Transplantation
Middle Aged
Allografts
Cord blood
Child, Preschool
Allogeneic hematopoietic stem cell transplantation
Acute Disease
Female
lcsh:Immunologic diseases. Allergy
Adult
long-term outcome
medicine.medical_specialty
Adolescent
Immunology
03 medical and health sciences
Sex Factors
Refractory
Non-hematological autoimmune diseases
Internal medicine
Humans
autoimmune diseases
allogeneic hematopoietic stem cell transplantation
Hematological autoimmune diseases
Retrospective Studies
business.industry
Infant
Retrospective cohort study
Long-term outcome
030104 developmental biology
business
lcsh:RC581-607
non-hematological autoimmune diseases
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology, Vol 10 (2019), Frontiers in Immunology, 10
- Accession number :
- edsair.doi.dedup.....b1c0b5772bd66b7038d19c8e3fa66160