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Modeling Human Mortality from All Diseases in the Five Most Populated Countries of the European Union
- Source :
- Bulletin of mathematical biology. 79(11)
- Publication Year :
- 2016
-
Abstract
- Age affects mortality from diseases differently than it affects mortality from external causes, such as accidents. Exclusion of the latter leads to the “all-diseases” category. The age trajectories of mortality from all diseases are studied in the five most populated countries of the EU, and the shape of these 156 age trajectories is investigated in detail. The arithmetic mean of ages where mortality reaches a minimal value is 8.47 years with a 95% confidence interval of [8.08, 8.85] years. Two simple deterministic models fit the age trajectories on the two sides of the mortality minimum. The inverse relationship is valid in all cases prior to this mortality minimum and death rates exactly decreased to three thousandths of its original size during the first 3000 days. After the mortality minimum, the standard Gompertz model fits the data in 63 cases, and the Gompertz model extended by a small quadratic element fits the remaining 93 cases. This analysis indicates that the exponential increase begins before the age of 15 years and that it is overshadowed by non-biological causes. Therefore, the existence of a mechanism switching that would explain the exponential increase in mortality after the age of 35 years is unlikely.
- Subjects :
- 0301 basic medicine
Adult
Male
Adolescent
General Mathematics
Immunology
Gompertz function
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Young Adult
0302 clinical medicine
Compensation law of mortality
media_common.cataloged_instance
Humans
European Union
European union
Mortality
Child
General Environmental Science
Mathematics
media_common
Aged
Pharmacology
Aged, 80 and over
Models, Statistical
General Neuroscience
Mortality rate
Age Factors
Infant, Newborn
Infant
Middle Aged
Confidence interval
030104 developmental biology
Computational Theory and Mathematics
Child, Preschool
Female
General Agricultural and Biological Sciences
Gompertz–Makeham law of mortality
030217 neurology & neurosurgery
Demography
Arithmetic mean
Quadratic element
Subjects
Details
- ISSN :
- 15229602
- Volume :
- 79
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Bulletin of mathematical biology
- Accession number :
- edsair.doi.dedup.....b1ac02aa85b09035cef5443ef3d11469