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Rapid and real-time detection of arginine enantiomers by QCM sensor having a Calix[4]arene receptor bearing asymmetric centers
- Source :
- Talanta. 204
- Publication Year :
- 2019
-
Abstract
- WOS: 000480664200019<br />PubMed: 31357279<br />This paper describes the sensing studies of a chiral calix[4]arene receptor (5) having (R)-2-phenylglycinol moiety for arginine enantiomers (D-/L-arginine) by using Quartz Crystal Microbalance (QCM) technique. The initial experiments have revealed that the chiral calix[4]arene 5 coated QCM (CCC-QCM) sensor showed good sensing for arginine enantiomers, such that it has exhibited higher sensing towards D-arginine than that of L-arginine. It has been determined that the sensitivity, limit of detection values of CCC-QCM sensor for the D-/L-arginine solutions as 0.024/0.023 Hz/mu M and 0.38/1.29 mu M, respectively. On the other hand, the racemic mixture studies were optimized using the response surface methodology with central composite design. Consequently, it has been demonstrated that the QCM sensor modification with a calix[4]arene receptor bearing asymmetric centers provided rapid, real-time, sensitive and effective sensing of arginine enantiomers.<br />Scientific and Technological Research Council of Turkey (TUBITAK-Grant)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115Z249]; Research Foundation of the Selcuk UniversitySelcuk University [16401003]; Konya, Turkey<br />We thank the Scientific and Technological Research Council of Turkey (TUBITAK-Grant Number 115Z249) and the Research Foundation of the Selcuk University (SUBAP-Grant Number 16401003), Konya, Turkey and for financial support of this work produced from Farabi Temel's Ph.D. Thesis.
- Subjects :
- Detection limit
Arginine
Central composite design
Chemistry
010401 analytical chemistry
02 engineering and technology
Quartz crystal microbalance
021001 nanoscience & nanotechnology
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Analytical Chemistry
Amino acid
Calixarene
Sensing
Racemic mixture
Moiety
Enantiomer
0210 nano-technology
Sensor
Subjects
Details
- ISSN :
- 18733573
- Volume :
- 204
- Database :
- OpenAIRE
- Journal :
- Talanta
- Accession number :
- edsair.doi.dedup.....b1ab5b5e2d925fcd07d1b489843cc7a0