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Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria
- Source :
- Journal of Inflammation (London, England)
- Publication Year :
- 2014
- Publisher :
- BioMed Central, 2014.
-
Abstract
- Background Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders. Aim To assess relationship between vitamin D status and C-reactive protein (CRP), a nonspecific inflammatory marker of CSU activity. Methods Concentrations of CRP and 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status were measured in serum of CSU patients and compared with the healthy controls. Results Serum 25(OH)D concentration was significantly lower in CSU group as compared with the normal subjects. The prevalence of vitamin D deficiency (< 20 ng/ml) was significantly higher in patients with CSU than among normal population. There were no significant differences in prevalence of 25(OH)D insufficiency between the groups. Serum CRP concentrations were significantly higher in CSU patients as compared with the healthy subjects. There were no significant correlations between CRP and 25(OH)D concentrations in CSU patients. Conclusions CSU is associated with lower serum 25(OH)D concentration and higher prevalence of its deficiency. The results failed to show any effect of vitamin D status on circulating CRP concentrations in CSU. A potential role of vitamin D in pathogenesis and/or additive therapy of CSU needs to be examined in other cohorts of CSU patients as well as in larger studies.
- Subjects :
- medicine.medical_specialty
Clinical Biochemistry
Acute phase response
Gastroenterology
vitamin D deficiency
C-reactive protein
Pathogenesis
Internal medicine
medicine
Vitamin D and neurology
Vitamin D
biology
business.industry
Incidence (epidemiology)
Research
Acute-phase protein
Cell Biology
medicine.disease
25-hydroxyvitamin D
Rheumatology
Immunology
biology.protein
Biomarker (medicine)
business
Chronic spontaneous urticaria (CSU)
Subjects
Details
- Language :
- English
- ISSN :
- 14769255
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Inflammation (London, England)
- Accession number :
- edsair.doi.dedup.....b1a792e34afbad6725c9e1244004265d