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Oxidative Nucleophilic Cyclization of 2-Alkynylanilines with Thiophenols under Metal-Free Conditions
- Source :
- Organic Letters. 16:6508-6511
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- An oxidative nucleophilic cyclization of 2-alkynylanilines with thiophenols under metal-free conditions was developed. The one-pot two-step reaction involves a PhI(OAc)2-mediated oxidative dearomatization and a Brønsted acid promoted nucleophilic cyclization. DFT calculations were performed to understand the reaction pathway.
- Subjects :
- Aniline Compounds
Molecular Structure
Chemistry
Organic Chemistry
Stereoisomerism
Oxidative phosphorylation
Biochemistry
Catalysis
Phenols
Nucleophile
Metal free
Cyclization
Metals
Quantum Theory
Organic chemistry
Sulfhydryl Compounds
Physical and Theoretical Chemistry
Brønsted–Lowry acid–base theory
Oxidation-Reduction
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....b1a53ebf8074860c18daa6e599f96f1e
- Full Text :
- https://doi.org/10.1021/ol5034139