In vitro activities of antifungal drugs against a large collection of Trichophyton tonsurans isolated from wrestlers

Background Trichophyton tonsurans is the most common agent causing tinea gladiatorum in wrestlers and limited data on susceptibility profiles of Trichophyton tonsurans is available. Objectives We aimed to assess the in vitro activity of the common antifungal drug against a large collection of T. tonsurans. Materials/methods The in vitro activities to eight common antifungal drugs (sertaconazole, itraconazole, clotrimazole, fluconazole, butenafine, tolnaftate, terbinafine, and griseofulvin) against 128 clinical isolates of T. tonsurans strains, obtained from wrestlers with dermatophytosis, was performed according to CLSI M38-A2 broth microdilution document. Results The geometric mean minimum inhibitory concentration was the lowest for tolnaftate (0.022 µg/ml), followed by itraconazole (0.026 µg/ml), terbinafine (0.033 µg/ml), butenafine (0.088 µg/ml), griseofulvin (0.566 µg/ml), sertaconazole (2.875 µg/ml), clotrimazole (3.419 µg/ml), and fluconazole (12.540 µg/ml). Conclusions Evaluation of antifungal susceptibility of dermatophytes showed that tolnaftate and itraconazole were the most effective drugs against Trichophyton tonsurans and fluconazole had the least effect.