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Interplay between Exosomes and Autophagy in Cardiovascular Diseases: Novel Promising Target for Diagnostic and Therapeutic Application
- Source :
- Aging and Disease
- Publication Year :
- 2019
- Publisher :
- JKL International LLC, 2019.
-
Abstract
- Exosome, is identified as a nature nanocarrier and intercellular messenger that regulates cell to cell communication. Autophagy is critical in maintenance of protein homeostasis by degradation of damaged proteins and organelles. Autophagy and exosomes take pivotal roles in cellular homeostasis and cardiovascular disease. Currently, the coordinated mechanisms for exosomes and autophagy in the maintenance of cellular fitness are now garnering much attention. In the present review, we discussed the interplay of exosomes and autophagy in the context of physiology and pathology of the heart, which might provide novel insights for diagnostic and therapeutic application of cardiovascular diseases.
- Subjects :
- 0301 basic medicine
autophagy
Cellular homeostasis
Context (language use)
Disease
Review
exosomes
Exosome
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Cell to cell communication
cardiovascular disease
Medicine
myocardial ischemia/reperfusion injury
business.industry
Autophagy
Cell Biology
Microvesicles
Cell biology
030104 developmental biology
Neurology (clinical)
Geriatrics and Gerontology
Nanocarriers
atherosclerosis
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 21525250
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Aging and Disease
- Accession number :
- edsair.doi.dedup.....b193ca162b419970816e9d97591f63e0