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Current Concepts of Psoriasis Immunopathogenesis
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 11574, p 11574 (2021), Volume 22, Issue 21
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is the most common inflammatory skin disease, affecting an average of 2–4% of the world’s population. The disease carries a significant burden due to its numerous comorbidities and the major impact on patients’ social and emotional aspects of life. According to current knowledge, psoriasis is a multifactorial disease that occurs in genetically predisposed individuals under various environmental factors, which trigger an immune response disorder with a series of complex inflammatory cascades. The disease is initiated and maintained by mutual interaction of the innate and adaptive immune cells, primarily dendritic cells, T lymphocytes, and keratinocytes, whose leading role alternates at different stages of the disease, consisting mainly in the IL-23/Th17 pathway. Inflammatory events result in consequent epidermal and dermal changes and evolution of the characteristic psoriatic phenotype, respectively. This paper aims to present a comprehensive overview of current knowledge on psoriasis genetic and environmental etiological factors, immunopathogenesis, and the leading cellular and cytokine participants in the inflammatory pathways of this disease.
- Subjects :
- keratinocytes
QH301-705.5
etiology
medicine.medical_treatment
Population
T lymphocytes
Review
NK cells
Disease
Catalysis
Inorganic Chemistry
Immune system
Psoriasis
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Dermatovenerologija
Animals
Humans
Medicine
dendritic cells
Biology (General)
Physical and Theoretical Chemistry
IL-23/Th17 pathway
education
QD1-999
Molecular Biology
Spectroscopy
Inflammation
education.field_of_study
business.industry
Organic Chemistry
immunopathogenesis
psoriasis
General Medicine
Atopic dermatitis
Natural killer T cell
medicine.disease
macrophages
NKT cells
Computer Science Applications
Chemistry
Phenotype
Cytokine
Immunology
Etiology
Cytokines
business
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Dermatovenerology
Signal Transduction
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....b18aca094b7acae6128ad59d6eacc3e9