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Recent developments and future directions in adult lower-grade gliomas: Society for Neuro-Oncology (SNO) and European Association of Neuro-Oncology (EANO) consensus
- Source :
- Neuro-oncology, vol 21, iss 7, Neuro-Oncology, 21(7), 837-853, Neuro-Oncology, 21(7), 837-853. Oxford University Press
- Publication Year :
- 2019
-
Abstract
- The finding that most grades II and III gliomas harbor isocitrate dehydrogenase (IDH) mutations conveying a relatively favorable and fairly similar prognosis in both tumor grades highlights that these tumors represent a fundamentally different entity from IDH wild-type gliomas exemplified in most glioblastoma. Herein we review the most recent developments in molecular neuropathology leading to reclassification of these tumors based upon IDH and 1p/19q status, as well as the potential roles of methylation profiling and deletional analysis of cyclin-dependent kinase inhibitor 2A and 2B. We discuss the epidemiology, clinical manifestations, benefit of surgical resection, and neuroimaging features of lower-grade gliomas as they relate to molecular subtype, including advanced imaging techniques such as 2-hydroxyglutarate magnetic resonance spectroscopy and amino acid PET scanning. Recent, ongoing, and planned studies of radiation therapy and both cytotoxic and targeted chemotherapies are summarized, including both small molecule and immunotherapy approaches specifically targeting the mutant IDH protein.
- Subjects :
- Oncology
Adult
Cancer Research
medicine.medical_specialty
lower-grade
medicine.medical_treatment
Oncology and Carcinogenesis
Neuroimaging
Neuropathology
Rare Diseases
Internal medicine
Glioma
glioma
Medical
medicine
Humans
Oncology & Carcinogenesis
astrocytoma
Cancer
business.industry
Brain Neoplasms
Neurosciences
Astrocytoma
Immunotherapy
medicine.disease
Prognosis
Combined Modality Therapy
IDH mutation
oligodendroglioma
Brain Disorders
Radiation therapy
Europe
Brain Cancer
Isocitrate dehydrogenase
Biomedical Imaging
Neurology (clinical)
Oligodendroglioma
Neoplasm Grading
business
Societies
Subjects
Details
- ISSN :
- 15228517
- Volume :
- 21
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Neuro-Oncology
- Accession number :
- edsair.doi.dedup.....b183fe2e36e98413f48ef85a48b0d3ba