Back to Search
Start Over
THE PERITONEUM AS A NOVEL OXYGENATION ORGAN
- Source :
- Shock. 30:250-253
- Publication Year :
- 2008
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2008.
-
Abstract
- Supplemental oxygenation is important in reversible pulmonary failure. To determine whether the peritoneal cavity can be used as a source of "extrapulmonary respiration," we perfused the peritoneal cavity with oxygenated red blood cells (RBCs) and saline, and measured the amount of oxygenation delivered through the peritoneum of dogs under controlled ventilation. Inflow and outflow catheters were placed in the peritoneal cavity and connected to a perfusion circuit. We investigated the safety of this procedure by examining the relationship between intraperitoneal infusion volume and hemodynamic changes in dogs that underwent peritoneal perfusion with oxygenated RBC (n = 6) and with oxygenated saline (n = 6). The controls comprised dogs that underwent a sham operation (n = 6). We found that an intraperitoneal infusion of less than 1,250 mL was hemodynamically safe. Oxygenation levels (PaO2) increased most obviously with an intraperitoneal infusion of oxygenated RBC. The peritoneum can potentially serve as an "artificial lung" in critically ill patients.
- Subjects :
- Male
medicine.medical_specialty
Erythrocytes
medicine.medical_treatment
Hemodynamics
Critical Care and Intensive Care Medicine
Models, Biological
Artificial lung
Peritoneal cavity
Dogs
Oxygen Consumption
Peritoneum
Respiration
medicine
Animals
Peritoneal Cavity
Saline
Pulmonary Gas Exchange
business.industry
Oxygenation
Carbon Dioxide
Respiration Disorders
Surgery
Oxygen
Perfusion
medicine.anatomical_structure
Emergency Medicine
business
Subjects
Details
- ISSN :
- 10732322
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Shock
- Accession number :
- edsair.doi.dedup.....b182236836762bc1484e08b3f0b4e86e