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Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals
- Source :
- AIDS, 36(2), 205-214. Lippincott Williams & Wilkins
- Publication Year :
- 2022
- Publisher :
- Lippincott Williams & Wilkins, 2022.
-
Abstract
- Objective: Persistence of the viral reservoir is the main barrier to curing HIV. Initiation of ART during acute HIV infection can limit the size and diversity of the reservoir. In depth characterization of the reservoir in individuals who initiate ART during acute infection will be critical for clinical trial design and cure strategies. Methods: Four cohortswith participantswhoinitiatedARTduring acute infection or during chronic infectionwere enrolled in a cross-sectional, noninterventional study.Viral reservoir was evaluated by the Intact Proviral DNA Assay (IPDA), the Total HIVDNA Assay (THDA) and the Quantitative Viral Outgrowth Assay (QVOA). Viral diversity and susceptibility to V3-glycan bNAbs were determined by genotyping of the viral envelope gene. Results: Participants who initiated ART during the acute Fiebig I-IV stages had lower level of total HIV DNA than participants who initiated ART during chronic infection whereas no difference was observed in intact HIV DNA or outgrowth virus. Participants who initiated ART during Fiebig I-IV also had lower viral diversity and appeared to have higher susceptibility to bNAbs than participants initiating ART during chronic infection. Conclusion: Individuals initiating ART during Fiebig I-IV had small viral reservoirs, low viral diversity, and high susceptibility to bNAbs, and would be an optimal target population for proof-of-concept HIV cure trials.
- Subjects :
- 10028 Institute of Medical Virology
Immunology
Human immunodeficiency virus (HIV)
Acute infection
HIV Infections
610 Medicine & health
medicine.disease_cause
Virus
10234 Clinic for Infectious Diseases
SDG 3 - Good Health and Well-being
medicine
Immunology and Allergy
Humans
Genotyping
Acute HIV infection
2403 Immunology
biology
business.industry
Viral Envelope Gene
2725 Infectious Diseases
Viral Load
Virology
Chronic infection
Infectious Diseases
Cross-Sectional Studies
Anti-Retroviral Agents
biology.protein
HIV-1
2723 Immunology and Allergy
570 Life sciences
Antibody
business
Broadly Neutralizing Antibodies
Subjects
Details
- Language :
- English
- ISSN :
- 14735571 and 02699370
- Volume :
- 36
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....b181d0bb75524747c5f63551167781f8