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Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma
- Source :
- The Journal of investigative dermatology. 139(8)
- Publication Year :
- 2018
-
Abstract
- Melasma is a pigmentary disorder characterized by hyperpigmented patchy skin in sun-exposed areas, especially the face. Treatment of melasma can be challenging because long-term therapy is required, reoccurrence is common, and existing therapies are insufficient and unsatisfactory. To investigate new treatment options, we performed an exploratory double-blinded, randomized split-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone in women with mild to moderate melasma. After 12 weeks, modified Melasma Area and Severity Index scores significantly improved on both the Thiamidol-treated and the hydroquinone-treated sides of the face. Additionally, Thiamidol treatment improved modified Melasma Area and Severity Index scores significantly better than hydroquinone, and more subjects improved following treatment with Thiamidol (79%) compared with hydroquinone (61%). During treatment, no subjects displayed worsening of modified Melasma Area and Severity Index scores on the Thiamidol-treated side, while approximately 10% of the subjects showed a worsening of modified Melasma Area and Severity Index scores on the hydroquinone-treated side. All subjects routinely used sunscreens and consistent results were obtained in low and in high UV ambient conditions. Subjects rated the efficacy of the Thiamidol formulation significantly better with regard to overall decreased intensity of dark spots and their overall appearance throughout the study. Thiamidol was well-tolerated and well-perceived and represents an effective agent to reduce hyperpigmentation.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Melasma
Tyrosinase
Skin Pigmentation
Dermatology
Administration, Cutaneous
Biochemistry
Tyrosinase inhibitor
Severity of Illness Index
Melanosis
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
medicine
Humans
Molecular Biology
Aged
business.industry
Monophenol Monooxygenase
Treatment options
Cell Biology
Resorcinols
Middle Aged
medicine.disease
Hyperpigmentation
Hydroquinones
030104 developmental biology
Treatment Outcome
030220 oncology & carcinogenesis
Face
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 15231747
- Volume :
- 139
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The Journal of investigative dermatology
- Accession number :
- edsair.doi.dedup.....b17bf8153ee24d0b6a66344bb397cad8