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Plasma Concentrations of Endocannabinoids and Related Primary Fatty Acid Amides in Patients with Post-Traumatic Stress Disorder
- Source :
- PLoS One, 8, PLoS ONE, Vol 8, Iss 5, p e62741 (2013), PLoS ONE, PLoS One, 8, 5
- Publication Year :
- 2013
-
Abstract
- Contains fulltext : 125746.pdf (Publisher’s version ) (Open Access) BACKGROUND: Endocannabinoids (ECs) and related N-acyl-ethanolamides (NAEs) play important roles in stress response regulation, anxiety and traumatic memories. In view of the evidence that circulating EC levels are elevated under acute mild stressful conditions in humans, we hypothesized that individuals with traumatic stress exposure and post-traumatic stress disorder (PTSD), an anxiety disorder characterized by the inappropriate persistence and uncontrolled retrieval of traumatic memories, show measurable alterations in plasma EC and NAE concentrations. METHODS: We determined plasma concentrations of the ECs anandamide (ANA) and 2-arachidonoylglycerol (2-AG) and the NAEs palmitoylethanolamide (PEA), oleoylethanolamide (OEA), stearoylethanolamine (SEA), and N-oleoyldopamine (OLDA) by HPLC-MS-MS in patients with PTSD (n = 10), trauma-exposed individuals without evidence of PTSD (n = 9) and in healthy control subjects (n = 29). PTSD was diagnosed according to DSM-IV criteria by administering the Clinician Administered PTSD Scale (CAPS), which also assesses traumatic events. RESULTS: Individuals with PTSD showed significantly higher plasma concentrations of ANA (0.48 +/- 0.11 vs. 0.36 +/- 0.14 ng/ml, p = 0.01), 2-AG (8.93 +/- 3.20 vs. 6.26+/-2.10 ng/ml, p
- Subjects :
- Adult
Male
Warfare
medicine.medical_specialty
Hydrocortisone
DCN MP - Plasticity and memory
Science
Torture
Clinician Administered PTSD Scale
Neurophysiology
Psychological Stress
Cohort Studies
Stress Disorders, Post-Traumatic
Oleoylethanolamide
chemistry.chemical_compound
Endocrinology
ddc:150
Internal medicine
Blood plasma
medicine
Humans
Psychology
Psychiatry
Palmitoylethanolamide
Multidisciplinary
Case-control study
Anandamide
medicine.disease
Amides
Anxiety Disorders
Clinical Psychology
Mental Health
chemistry
Case-Control Studies
Medicine
Female
Stress, Psychological
Anxiety disorder
Endocannabinoids
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS One, 8, PLoS ONE, Vol 8, Iss 5, p e62741 (2013), PLoS ONE, PLoS One, 8, 5
- Accession number :
- edsair.doi.dedup.....b178e2c6aa9944c605fcd1383d6b29a2