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Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi
- Source :
- Oncology Letters
- Publication Year :
- 2016
- Publisher :
- Spandidos Publications, 2016.
-
Abstract
- The TGF-β associated growth factor Nodal is highly expressed in aggressive metastatic melanoma. Determining the risk for melanomagenesis from Nodal expression in nevi prior to the development of melanoma may be useful for both the screening and prevention of melanoma. Tissue sections of human adult nevi with or without a history of melanoma were stained by immunohistochemistry (IHC) for Nodal, the Nodal co-receptor Cripto-1, and Notch4, which have previously been shown to be associated with Nodal expression in melanoma. The degree of Nodal, Cripto-1 and Notch4 staining was scored and correlated with available clinical data. Median IHC scores for Nodal, Cripto-1 and Notch4 expression were significantly higher in nevi removed from patients who eventually developed melanoma compared with nevi from patients with no history of melanoma. In addition, the degree of Nodal expression in nevi from patients who eventually developed melanoma correlated significantly with the Breslow depth of the melanoma. Expression of Nodal and components of its signaling pathway in nevi may represent a biomarker for selecting a unique subset of patients requiring increased surveillance for screening and prevention of melanoma.
- Subjects :
- 0301 basic medicine
Cancer Research
Nodal
Biology
Cripto
03 medical and health sciences
0302 clinical medicine
melanoma
medicine
Nevus
skin and connective tissue diseases
neoplasms
integumentary system
screening
Melanoma
Notch4
Cancer
Articles
medicine.disease
Cripto-1
Molecular medicine
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
immunohistochemistry
Cancer research
biomarker
Biomarker (medicine)
Immunohistochemistry
NODAL
nevus
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....b17245ca7a5823e9dc725f19ab2cd782