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Fermentation of Ferulated Arabinoxylan Recovered from the Maize Bioethanol Industry
- Source :
- Processes, Processes, MDPI, 2021, 9 (1), pp.165. ⟨10.3390/pr9010165⟩, Processes, Vol 9, Iss 165, p 165 (2021)
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; Maize by-product from the bioethanol industry (distiller’s dried grains with solubles, DDGS) is a source of ferulated arabinoxylan (AX), which is a health-promoting polysaccharide. In the present study, AX from DDGS was fermented by a representative colonic bacterial mixture (Bifidobacterium longum, Bifidobacterium adolescentis, and Bacteroides ovatus), and the effect of the fermented AX (AX-f) on the proliferation of the cell line Caco-2 was investigated. AX was efficiently metabolized by these bacteria, as evidenced by a decrease in the polysaccharide molecular weight from 209 kDa to < 50 kDa in AX-f, the release of ferulic acid (FA) from polysaccharide chains (1.14 µg/mg AX-f), and the short-chain fatty acids (SCFA) production (277 µmol/50 mg AX). AX-f inhibited the proliferation of Caco-2 cells by 80–40% using concentrations from 125–1000 µg/mL. This dose-dependent inverse effect was attributed to the increased viscosity of the media due to the polysaccharide concentration. The results suggest that the AX-f dose range and the SCFA and free FA production are key determinants of antiproliferative activity. Using the same polysaccharide concentrations, non-fermented AX only inhibited the Caco-2 cells proliferation by 8%. These findings highlight the potential of AX recovered from the maize bioethanol industry as an antiproliferative agent once fermented by colonic bacteria
- Subjects :
- 0301 basic medicine
Bifidobacterium longum
genetic structures
030106 microbiology
Bioengineering
Polysaccharide
lcsh:Chemical technology
Ferulic acid
lcsh:Chemistry
03 medical and health sciences
chemistry.chemical_compound
Arabinoxylan
[SDV.IDA]Life Sciences [q-bio]/Food engineering
Chemical Engineering (miscellaneous)
lcsh:TP1-1185
[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering
Food science
fermentation
2. Zero hunger
chemistry.chemical_classification
antiproliferative agent
biology
Process Chemistry and Technology
food and beverages
biology.organism_classification
030104 developmental biology
chemistry
lcsh:QD1-999
colon cancer
Cell culture
Biofuel
Fermentation
ferulated arabinoxylan
Bacteria
ferulic acid
Subjects
Details
- Language :
- English
- ISSN :
- 22279717
- Database :
- OpenAIRE
- Journal :
- Processes, Processes, MDPI, 2021, 9 (1), pp.165. ⟨10.3390/pr9010165⟩, Processes, Vol 9, Iss 165, p 165 (2021)
- Accession number :
- edsair.doi.dedup.....b171aa4ef6412813d7217ce2a7006f10