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Respiratory and cardiac effects of metoprolol and bevantolol in patients with asthma
- Source :
- Clinical Pharmacology and Therapeutics. 39:29-34
- Publication Year :
- 1986
- Publisher :
- Springer Science and Business Media LLC, 1986.
-
Abstract
- The effects on standing heart rate and respiratory function of two relatively selective beta 1-adrenoceptor antagonists, metoprolol and bevantolol, were compared in a double-blind, randomized, crossover study of 16 patients with asthma. After control observations on 2 separate days, the patients received approximately equivalent cardiac beta-adrenoceptor antagonist doses of metoprolol, 12.5, 25, 50, and 100 mg, and bevantolol, 18.75, 37.5, 75 and 150 mg, at intervals of 2 hours. Dosing was stopped if symptoms warranted or if there was a fall of greater than or equal to 20% in the forced expiratory volume in 1 second. In general, the cumulative dosing regimen proved a safe and effective means of assessing bronchial responsiveness to these beta-blockers in asthma, but one patient had to be dropped from the study because of severe bronchoconstriction after the first dose. Of the 15 patients studied who were taking both drugs, seven patients were withdrawn prematurely. In these seven patients, the average maximum tolerated cumulative doses were 45.5 mg bevantolol and 26.8 mg metoprolol, doses that are much lower than those usually required for therapeutic activity. The respiratory response to either drug could not be predicted.
- Subjects :
- Adult
Male
Spirometry
Administration, Oral
Propanolamines
Random Allocation
Double-Blind Method
Heart Rate
Heart rate
medicine
Humans
Pharmacology (medical)
Respiratory function
Dosing
Lung
Aged
Maximal Expiratory Flow Rate
Metoprolol
Asthma
Pharmacology
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
Crossover study
Bevantolol
Anesthesia
Drug Evaluation
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15326535 and 00099236
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....b16c2f1649c836d7bc4b5ebad79a9741