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Synthesis of Novel Pyrrolo-[3,2-c]quinolines via Iron-Catalyzed Cross-Coupling Reaction of Grignard Reagents
- Source :
- Synthetic Communications, Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2009, 39, pp.1583-1591. ⟨10.1080/00397910802550039⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; Cross-coupling reaction of alkyl and aryl magnesium halides with 4-chloro-pyrrolo[3,2-c]quinoline in the presence of a catalytic amount of iron salt is described. The reactions are completed in 30 min, resulting in moderate to excellent yields of 52-94% in a tetrahydrofuran (THF)-N-methylpyrrolidinone NMP solvent mixture
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Magnesium
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Aryl
organomagnesium reagents
Organic Chemistry
Quinoline
chemistry.chemical_element
010402 general chemistry
01 natural sciences
Medicinal chemistry
Coupling reaction
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Reagent
Organic chemistry
Cross-coupling
imidoyl chloride
nitrogen heterocycles
Alkyl
Tetrahydrofuran
iron catalysis
Subjects
Details
- Language :
- English
- ISSN :
- 00397911 and 15322432
- Database :
- OpenAIRE
- Journal :
- Synthetic Communications, Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2009, 39, pp.1583-1591. ⟨10.1080/00397910802550039⟩
- Accession number :
- edsair.doi.dedup.....b16c067de94bf63f2f4c99a03df902c4
- Full Text :
- https://doi.org/10.1080/00397910802550039⟩