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Bacteria-Mediated Tumor Therapy via Photothermally-Programmed Cytolysin A Expression
- Source :
- Small (Weinheim an der Bergstrasse, Germany). 17(40)
- Publication Year :
- 2021
-
Abstract
- By leveraging the ability of bacteria to express therapeutic protein cytolysin A (ClyA) through plasmid transformation, a thermally-activated biohybrid (TAB@Au) is constructed by biomineralizing gold nanoparticles (AuNPs) on the E. coli surface. Due to the feature of anaerobic bacteria homing to tumor microenvironments, the bacteria-based antitumor vehicles can be efficaciously accumulated at tumor sites. Under NIR laser irradiation, the biomineralized AuNPs harvest transdermal photons and convert them into local heat for photothermal therapy. After that, the produced heat elicits the expression of ClyA for killing tumor cells. In vitro and in vivo experiments verify the conception that the current therapeutic modality greatly inhibits the proliferation of tumor cells. In terms of the spatial specificity and non-invasiveness of NIR laser, the bacteria-based phototherapy represents an appealing way for tumor therapy.
- Subjects :
- Tumor microenvironment
biology
Chemistry
Cytotoxins
Metal Nanoparticles
General Chemistry
Photothermal therapy
Phototherapy
biology.organism_classification
In vitro
Cell biology
Biomaterials
Transformation (genetics)
In vivo
Cell Line, Tumor
Escherichia coli
General Materials Science
Cytolysin
Anaerobic bacteria
Gold
Bacteria
Biotechnology
Subjects
Details
- ISSN :
- 16136829
- Volume :
- 17
- Issue :
- 40
- Database :
- OpenAIRE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Accession number :
- edsair.doi.dedup.....b1667eefc546ba9c9b0959c9f041c53b