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Hepatoprotective Effect of Opuntia robusta Fruit Biocomponents in a Rat Model of Thioacetamide-Induced Liver Fibrosis

Authors :
Nayeli Amalinalli Pulido-Hornedo
Javier Ventura-Juárez
Fidel Guevara-Lara
Herson Antonio González-Ponce
Esperanza Sánchez-Alemán
Manon Buist-Homan
Han Moshage
Ma. Consolación Martínez-Saldaña
Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
Center for Liver, Digestive and Metabolic Diseases (CLDM)
Source :
Plants, 11(15):2039, Plants; Volume 11; Issue 15; Pages: 2039
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Liver fibrosis is a chronic disease associated with oxidative stress that has a great impact on the population mortality. Due to their antioxidant capacity, we evaluated the protective effect of Opuntia robusta fruit (Or) on liver fibrosis. A nutraceutical characterization of Or was performed and a model of fibrosis was induced with thioacetamide (TAA) in Wistar rats. Aminotransferases, reduced glutathione (GSH) and histopathology were evaluated. Or contained 436.5 ± 57 mg of Betacyanins equivalents/L., 793 mg of catechin equivalents (CAE)/100 g for flavonoids, 1118 mg of gallic acid equivalents (GAE)/100 g for total phenols, 141.14 mg/100 g for vitamin C and 429.9 μg/100 g for vitamin E. The antioxidant capacity of Or was: 2.27 mmol of Trolox® equivalents (TE)/L (DPPH), 62.2 ± 5.0 μmol TE/g (ABTS•+), 80.2 ± 11.7 μmol TE/g (FRAP), 247.9 ± 15.6 µmol TE/g (AAPH) and 15.0% of H2O2 elimination. An increase (p < 0.05) of aminotransferases and a decrease (p < 0.05) of hepatic GSH was observed in the TAA group compared to the control and the concomitant groups. Histopathology showed changes in the normal architecture of the liver treated with TAA compared to the concomitant treatments. Or contains bioactive components with antioxidant capacity, which can reduce fibrotic liver damage.

Details

ISSN :
22237747
Volume :
11
Database :
OpenAIRE
Journal :
Plants
Accession number :
edsair.doi.dedup.....b16571b1c6665fc680694476f3ca0faa
Full Text :
https://doi.org/10.3390/plants11152039