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Experimental diffuse brain injury results in regional alteration of gross vascular morphology independent of neuropathology
- Source :
- Brain Injury. 30:217-224
- Publication Year :
- 2015
- Publisher :
- Informa UK Limited, 2015.
-
Abstract
- A dynamic relationship exists between diffuse traumatic brain injury and changes to the neurovascular unit. The purpose of this study was to evaluate vascular changes during the first week following diffuse TBI. It was hypothesized that pathology is associated with modification of the vasculature.Male Sprague-Dawley rats underwent either midline fluid percussion injury or sham-injury. Brain tissue was collected 1, 2 or 7 days post-injury or sham-injury (n = 3/time point). Tissue was collected and stained by de Olmos amino-cupric silver technique to visualize neuropathology or animals were perfused with AltaBlue casting resin before high-resolution vascular imaging. The average volume, surface area, radius, branching and tortuosity of the vessels were evaluated across three regions of interest.In M2, average vessel volume (p0.01) and surface area (p0.05) were significantly larger at 1 day relative to 2 days, 7 days and sham. In S1BF and VPM, no significant differences in the average vessel volume or surface area at any of the post-injury time points were observed. No significant changes in average radius, branching or tortuosity were observed.Preliminary findings suggest gross morphological changes within the vascular network likely represent an acute response to mechanical forces of injury, rather than delayed or chronic pathological processes.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Traumatic brain injury
Neuroscience (miscellaneous)
Neuropathology
Article
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Brain Injuries, Diffuse
Developmental and Educational Psychology
medicine
Animals
Diffuse traumatic brain injury
Vascular imaging
business.industry
Brain
Anatomy
medicine.disease
Neurovascular bundle
Rats
Disease Models, Animal
030104 developmental biology
Vascular morphology
Fluid percussion
Neurology (clinical)
Diffuse brain injury
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1362301X and 02699052
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Brain Injury
- Accession number :
- edsair.doi.dedup.....b163e7961f8c06353b99d3aa30f83781