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Investigation of blood coagulation effect of nonthermal multigas plasma jetinvitroandinvivo
- Source :
- Journal of Surgical Research. 219:302-309
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- Background Nonthermal atmospheric pressure plasma (NTAPP) has recently received attention as a novel tool in medicine. It is thought that plasma components yield plasma effects such as sterilization, blood coagulation, and wound healing. These effects are produced without thermal damage. We investigated the blood coagulation effect of NTAPP by using a multigas plasma jet. Materials and methods Multigas plasma jets can generate NTAPP by several gas species. In this study, argon, oxygen, helium, nitrogen, mock air, and carbon dioxide were used to generate NTAPP, and blood coagulation times were compared with each plasma-treated sample. The NTAPP blood coagulation effects on whole blood with four different anticoagulants were investigated. In addition, in this study, the effects of plasma treatment on porcine tissues and organs were investigated as in vivo experiment. Results A tendency to coagulate later with argon gas plasma than others was shown. There were no significant differences between oxygen, helium, nitrogen, mock air, and carbon dioxide. Whole blood with each anticoagulant demonstrated fast coagulation by NTAPP treatment. Fast control of the bleeding lesions on porcine stomach and liver by plasma treatment was observed, and no tissue damage due to the plasma treatment was detected by optical microscope. Conclusions These experiments suggest the potential of various gas NTAPPs as a novel medical device to control bleeding lesions.
- Subjects :
- Plasma Gases
Swine
medicine.drug_class
chemistry.chemical_element
Atmospheric-pressure plasma
01 natural sciences
Oxygen
010305 fluids & plasmas
In vivo
0103 physical sciences
medicine
Animals
Humans
Whole blood
Multigas plasma
010302 applied physics
Argon
Chromatography
Hemostatic Techniques
Anticoagulant
Atmospheric pressure plasma
Plasma
Blood coagulation
Healthy Volunteers
Endoscopes, Gastrointestinal
chemistry
Hemostasis
Hemostasis/ Low temperature plasma
Cold plasma
Female
Surgery
Gastrointestinal Hemorrhage
Subjects
Details
- Language :
- English
- Volume :
- 219
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Research
- Accession number :
- edsair.doi.dedup.....b1624f7fdb1baa7270d77849e9da27f2