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Plasma endothelin levels in chronic ethanol fed rats: relationship to pathologic liver injury
- Source :
- Life Sciences. 54:423-428
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- We used the intragastric feeding rat model for alcohol liver disease to investigate the relationship between endothelin and pathologic liver injury. Rats were fed the following diets for periods of 1, 2 and 4 weeks: corn oil plus ethanol (CE), corn oil plus dextrose (CD) and saturated fat plus ethanol (SE). Plasma endothelin levels were significantly higher in the CE group compared to the other groups at all time periods studied. The CE animals, also, developed pathologic liver injury which is in contrast to the SE and CD animals which showed no pathologic changes. We propose that endothelin, because of its powerful vasoconstrictive effects, leads to a reduction in hepatic blood flow which is important in the pathogenesis of alcoholic liver disease.
- Subjects :
- Alcoholic liver disease
medicine.medical_specialty
Saturated fat
General Biochemistry, Genetics and Molecular Biology
Liver disease
Dietary Fats, Unsaturated
Internal medicine
medicine
Animals
General Pharmacology, Toxicology and Pharmaceutics
Liver Diseases, Alcoholic
Liver injury
Ethanol
business.industry
Endothelins
General Medicine
medicine.disease
Dietary Fats
Rats
Endocrinology
Liver
Toxicity
medicine.symptom
Endothelin receptor
business
Vasoconstriction
Corn oil
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....b15c5533714a11eba09853036f308fc4