Back to Search
Start Over
Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Fibromyalgia syndrome (FM) is a multifactorial disorder whose pathogenesis and diagnosis are poorly understood. This study investigated differential serum proteome profiles in patients with FM and healthy pain-free controls and explored the association between serum proteome and clinical profiles in patients with FM. Twenty patients with FM (according to the American College of Rheumatology criteria, 2010) and 20 healthy pain-free controls were recruited for optimized quantitative serum proteomics analysis. The levels of pain, pressure pain threshold, sleep, anxiety, depression, and functional status were evaluated for patients with FM. We identified 22 proteins differentially expressed in FM when compared with healthy pain-free controls and propose a panel of methyltransferase-like 18 (METTL18), immunoglobulin lambda variable 3–25 (IGLV3–25), interleukin-1 receptor accessory protein (IL1RAP), and IGHV1OR21-1 for differentiating FM from controls by using a decision tree model (accuracy: 0.97). In addition, we noted several proteins involved in coagulation and inflammation pathways with distinct expression patterns in patients with FM. Novel proteins were also observed to be correlated with the levels of pain, depression, and dysautonomia in patients with FM. We suggest that upregulated inflammation can play a major role in the pathomechanism of FM. The differentially expressed proteins identified may serve as useful biomarkers for diagnosis and evaluation of FM in the future.
- Subjects :
- medicine.medical_specialty
Science
Inflammation
Article
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Receptor
Depression (differential diagnoses)
030203 arthritis & rheumatology
Multidisciplinary
biology
business.industry
Dysautonomia
Rheumatology
Immunology
biology.protein
Anxiety
Medicine
medicine.symptom
Antibody
business
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....b150314c0dd2ca82b2b34e942c9c147a