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Efficacy and safety of raltegravir in treatment-experienced HIV-1-infected patients switching from enfuvirtide-based regimens: 48 week results of the randomized EASIER ANRS 138 trial
- Source :
- The Journal of antimicrobial chemotherapy. 66(9)
- Publication Year :
- 2011
-
Abstract
- OBJECTIVES: To assess the sustainable efficacy and safety of a switch from enfuvirtide to raltegravir in patients with multidrug-resistant HIV infection. METHODS: One hundred and seventy patients with multidrug-resistant HIV infection and suppressed plasma HIV RNA levels < 400 copies/mL under an enfuvirtide-based regimen were randomized to maintain their regimen or to switch to a raltegravir-based regimen (immediate group) in a 48 week prospective, randomized, open-label trial. At week 24, patients in the maintenance arm also switched to raltegravir (deferred group). Baseline genotypic susceptibility scores (GSSs) were calculated using available historical resistance tests. Efficacy was assessed by the cumulative proportion of patients with virological failure, defined as a confirmed plasma HIV RNA ≥ 400 copies/mL up to week 48. The EASIER ANRS 138 trial is registered at ClinicalTrials.gov (NCT00454337). RESULTS: At baseline, 86% of patients had plasma HIV RNA levels
- Subjects :
- Microbiology (medical)
Adult
Male
medicine.medical_specialty
Enfuvirtide
Genotype
Endpoint Determination
HIV Infections
Pilot Projects
Microbial Sensitivity Tests
Drug Resistance, Multiple, Viral
HIV Fusion Inhibitors
Internal medicine
Raltegravir Potassium
medicine
Humans
Pharmacology (medical)
HIV Integrase Inhibitors
Prospective Studies
Prospective cohort study
Darunavir
Pharmacology
business.industry
Alanine Transaminase
Middle Aged
Raltegravir
HIV Envelope Protein gp41
Peptide Fragments
Pyrrolidinones
Discontinuation
CD4 Lymphocyte Count
Regimen
Infectious Diseases
Treatment Outcome
HIV-1
RNA, Viral
Ritonavir
Female
France
business
Tipranavir
medicine.drug
Subjects
Details
- ISSN :
- 14602091
- Volume :
- 66
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The Journal of antimicrobial chemotherapy
- Accession number :
- edsair.doi.dedup.....b14f1745b15001ace4ee7c2a56a95a88