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Reductive Stress Linked to Small HSPs, G6PD, and Nrf2 Pathways in Heart Disease
- Source :
- Antioxidants & Redox Signaling. 18:1114-1127
- Publication Year :
- 2013
- Publisher :
- Mary Ann Liebert Inc, 2013.
-
Abstract
- Significance: Aerobic organisms must exist between the dueling biological metabolic processes for energy and respiration and the obligatory generation of reactive oxygen species (ROS) whose deleterious consequences can reduce survival. Wide fluctuations in harmful ROS generation are circumvented by endogenous countermeasures (i.e., enzymatic and nonenzymatic antioxidants systems) whose capacity decline with aging and are enhanced by disease states. Recent Advances: Substantial efforts on the cellular and molecular underpinnings of oxidative stress has been complemented recently by the discovery that reductive stress similarly predisposes to inheritable cardiomyopathy, firmly establishing that the biological extremes of the redox spectrum play essential roles in disease pathogenesis. Critical Issues: Because antioxidants by nutritional or pharmacological supplement to prevent or mitigate disease states have been largely disappointing, we hypothesize that lack of efficacy of antioxidants might be related to adverse outcomes in responders at the reductive end of the redox spectrum. As emerging concepts, such as reductive, as opposed, oxidative stress are further explored, there is an urgent and critical gap for biochemical phenotyping to guide the targeted clinical applications of therapeutic interventions. Future Directions: New approaches are vitally needed for characterizing redox states with the long-term goal to noninvasively assess distinct clinical states (e.g., presymptomatic, end-stage) with the diagnostic accuracy to guide personalized medicine. Antioxid. Redox Signal. 18, 1114–1127.
- Subjects :
- Glutathione metabolism
Heart Diseases
Heart disease
NF-E2-Related Factor 2
Physiology
Recombinant Fusion Proteins
Clinical Biochemistry
Disease
Glucosephosphate Dehydrogenase
Disease pathogenesis
Biology
medicine.disease_cause
Biochemistry
Antioxidants
Mice
chemistry.chemical_compound
Thioredoxins
Lack of efficacy
medicine
Animals
Humans
Precision Medicine
Molecular Biology
Heat-Shock Proteins
Reactive nitrogen species
General Environmental Science
chemistry.chemical_classification
Reactive oxygen species
Superoxide Dismutase
Models, Cardiovascular
alpha-Crystallin B Chain
Cell Biology
Forum Review Articles
Catalase
medicine.disease
Glutathione
Reactive Nitrogen Species
Acetylcysteine
Neoplasm Proteins
Cell biology
Disease Models, Animal
Early Diagnosis
Peroxidases
chemistry
General Earth and Planetary Sciences
Reactive Oxygen Species
Oxidative stress
Molecular Chaperones
Subjects
Details
- ISSN :
- 15577716 and 15230864
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Antioxidants & Redox Signaling
- Accession number :
- edsair.doi.dedup.....b13fb6539a2094d9591b42120ad2d058