Back to Search
Start Over
Supramaximal Stimulus Intensity as a Diagnostic Tool in Chronic Demyelinating Neuropathy
- Source :
- Neuroscience Journal, Neuroscience Journal, Vol 2016 (2016)
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Objective. The ability to correctly identify chronic demyelinating neuropathy can have important therapeutic and prognostic significance. The stimulus intensity value required to obtain a supramaximal compound muscle action potential amplitude is a commonly acquired data point that has not been formally assessed as a diagnostic tool in routine nerve conduction studies to identify chronic neuropathies. We postulated that this value was significantly elevated in chronic demyelinating neuropathy. Methods. We retrospectively reviewed electrophysiology laboratory records to compare the stimulus intensity values recorded during median and ulnar motor nerve conduction studies. The groups studied included normal controls (n=42) and the following diagnostic categories: chronic inflammatory demyelinating neuropathy (CIDP) (n=20), acquired inflammatory demyelinating neuropathy (AIDP) (n=13), Charcot Marie Tooth (CMT) type 1 or 4C (n=15), carpal tunnel syndrome (CTS) (n=11), and amyotrophic lateral sclerosis (ALS) (n=18). Results. Supramaximal intensities were significantly higher in patients with CMT (median nerve: 43.4 mA) and CIDP (median nerve: 38.9 mA), whereas values similar to normal controls (median nerve: 25.3 mA) were obtained in ALS, CTS, and AIDP. Conclusions. Supramaximal stimulus intensity may be used as an additional criterion to identify the pathophysiology of neuropathy. We postulate that endoneurial hypertrophic changes may increase electrical impedance and thus the threshold of excitation at nodes of Ranvier.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Article Subject
business.industry
Stimulus (physiology)
medicine.disease
Pathophysiology
Median nerve
Nerve conduction velocity
lcsh:RC321-571
Surgery
Compound muscle action potential
03 medical and health sciences
Electrophysiology
030104 developmental biology
0302 clinical medicine
Internal medicine
medicine
Cardiology
Amyotrophic lateral sclerosis
business
Carpal tunnel syndrome
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
030217 neurology & neurosurgery
Research Article
Subjects
Details
- ISSN :
- 23144270 and 23144262
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Neuroscience Journal
- Accession number :
- edsair.doi.dedup.....b13ca0cca45326a9b962c39fa6a3bd5f