A REVIEW OF PHOSPHATIDYLSERINE PHARMACOLOGICAL AND CLINICAL EFFECTS. IS PHOSPHATIDYLSERINE A DRUG FOR THE AGEING BRAIN?

INTRODUCTION the first compound have been demonstrated on theCNS [7], and of the second on immune responses [8].The history of phosphatidylserine (PtdSer) beganmore than 50 years ago with its identification byFolch [1], as a constituent of the cephaline fraction, up BIOCHEMICAL ACTIONSto its clinical use for the treatment of the ‘ageingbrain’ [2]. This use remains a matter of debate [3]. PtdSer is the most effective acidic phospholipid inDuring these 50 years PtdSer has been the object of a activating the different protein kinase C isoforms [9].large number of investigations aimed at defining the A stimulation of the (Na