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RESULTS OF TONSILLECTOMY AND STEROID PULSE THERAPY IN 20 CASES OF RECURRENT IgA NEPHROPATHY AFTER KIDNEY TRANSPLANTATION
- Source :
- The Japanese Journal of Urology. 110:92-99
- Publication Year :
- 2019
- Publisher :
- Japanese Urological Association, 2019.
-
Abstract
- (Background) The standard treatment for recurrent immunoglobulin A nephropathy (rIgAN) after kidney transplantation (KTx) has not been established. (Methods) The results of treatment consisting of tonsillectomy and steroid pulse therapy in 20 recipients who were diagnosed as rIgAN were retrospectively analyzed. (Results) The level of proteinuria significantly decreased from 0.84±0.81 g/day to 0.27±0.31 g/day after treatment (P=0.007). Microscopic hematuria disappeared or improved in 58.3% and 66.6% of recipients 6 and 12 months after treatment, respectively. Serum creatinine levels remained stable for 5 years by the treatment, except for 3 cases of graft loss. Sixteen recipients received renal graft biopsies before and after treatment. Mesangial IgA deposition were dramatically decreased in 7 recipients (43.75%). The degree of mesangial hypercellularity, endocapillary hypercellularity, and crescents formation improved in 3 (18.8%), 6 (37.5%), and 4 (25%) recipients after treatment. (Conclusion) Steroid pulse therapy combined with tonsillectomy may be clinically and histopathologically effective treatment for rIgAN after KTx.
- Subjects :
- Adult
Male
medicine.medical_specialty
Urology
medicine.medical_treatment
Mesangial hypercellularity
Nephropathy
Young Adult
chemistry.chemical_compound
Recurrence
medicine
Humans
Endocapillary hypercellularity
Kidney transplantation
Retrospective Studies
Tonsillectomy
Creatinine
Proteinuria
business.industry
Standard treatment
Glomerulonephritis, IGA
medicine.disease
Kidney Transplantation
Treatment Outcome
chemistry
Pulse Therapy, Drug
Female
Steroids
medicine.symptom
business
Subjects
Details
- ISSN :
- 18847110 and 00215287
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- The Japanese Journal of Urology
- Accession number :
- edsair.doi.dedup.....b13536a01c3b8d98ba4a74213ee074eb