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Response to lithium prophylaxis: Interaction between serotonin transporter andBDNF genes
- Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :820-823
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Both serotonin transporter and brain-derived neurotrophic factor (BDNF) genes have been previously implicated in the efficacy of lithium prophylaxis. The aim of the present study was to assess a possible interaction between serotonin transporter genotype (5HTTLPR) and BDNF Val66Met polymorphism, and the prophylactic response to lithium. The study was performed on 111 patients with bipolar mood disorders (43 male, 68 female), aged 30–77 (mean 54 years) who have been treated with lithium carbonate for at least 5 years (5–27 years, mean 15 years). In the group studied, 31 patients (28%) were classified as excellent responders (ER), 54 (49%) as partial responders (PR), and 26 (23%) as non-responders (NR) to lithium prophylaxis. Age at onset of the illness, duration of illness before treatment introduction and on lithium as well as number of affective episodes before lithium treatment did not differ between these three subgroups of patients. A significant interaction between BDNF and 5HTTLPR polymorphism and lithium response was found. S individuals (patients with s/s or s/l genotype) having Val/Val genotype were significantly more frequent in NR compared with ER or/and PR. Also, S individuals showed extreme differences in response to lithium prophylaxis depending on having either Val/Val or (Val/Met + Met/Met) genotypes of BDNF polymorphism: 9/48 (19%) of ER and 18/48 (37%) of NR in the first group, and 12/30 (40%) and 1/30 (3%) in the second group, respectively. The results obtained may show a significant epistatic interaction between 5-HTTLPR and BDNF polymorphism, and response to lithium prophylaxis. © 2007 Wiley-Liss, Inc.
- Subjects :
- Adult
Male
medicine.medical_specialty
Bipolar Disorder
Genotype
Lithium (medication)
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Lithium Carbonate
Antimanic Agents
Polymorphism (computer science)
Internal medicine
medicine
Humans
Bipolar disorder
Genetics (clinical)
Serotonin transporter
Aged
Serotonin Plasma Membrane Transport Proteins
Genetics
Polymorphism, Genetic
biology
business.industry
Brain-Derived Neurotrophic Factor
Lithium carbonate
Middle Aged
medicine.disease
Psychiatry and Mental health
Endocrinology
Mood disorders
chemistry
biology.protein
Female
Serotonin
business
medicine.drug
Subjects
Details
- ISSN :
- 1552485X and 15524841
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Accession number :
- edsair.doi.dedup.....b12898a0b5ced0ddff5f1528998cb0fb