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Prophylaxis against Staphylococcus aureus vascular graft infection with mupirocin-soaked, collagen-sealed dacron
- Source :
- The Journal of surgical research. 99(2)
- Publication Year :
- 2001
-
Abstract
- A rat model was used to investigate the efficacy of mupirocin in the prevention of vascular prosthetic graft infections. The effect of mupirocin-soaked Dacron was compared with the effect of rifampin-soaked, collagen-sealed Dacron in the rat model of graft infection caused by methicillin-susceptible Staphylococcus aureus and methicillin-resistant S. aureus . Graft infections were established in the back subcutaneous tissue of 195 adult male Wistar rats by implantation of 1-cm 2 Dacron prostheses followed by topical inoculation with 5 × 10 7 colony-forming units of S. aureus . The study included a control group (no graft contamination), two contaminated groups that did not receive any antibiotic prophylaxis, two contaminated groups in which perioperative intraperitoneal amoxicillin clavulanate prophylaxis (50 mg/kg) was administered, four contaminated groups that received mupirocin- or rifampin-soaked graft, and four contaminated groups that received mupirocin- or rifampin-soaked graft and perioperative intraperitoneal amoxicillin clavulanate prophylaxis (50 mg/kg). The grafts were sterilely removed 7 days after implantation and the infection was evaluated by using sonication and quantitative agar culture. Data analysis showed that the efficacy of mupirocin against both strains was significantly different from that of the untreated control. In addition, mupirocin was more effective than rifampin against the methicillin-resistant strain. Finally, only the combination of mupirocin and amoxicillin clavulanate produced complete suppression of growth of all strains.
- Subjects :
- Male
medicine.medical_specialty
Staphylococcus aureus
Micrococcaceae
medicine.drug_class
Antibiotics
Mupirocin
medicine.disease_cause
Amoxicillin-Potassium Clavulanate Combination
chemistry.chemical_compound
Medicine
Animals
Antibiotic prophylaxis
Rats, Wistar
Antibiotics, Antitubercular
Antibacterial agent
biology
business.industry
Polyethylene Terephthalates
Staphylococcal Infections
biology.organism_classification
Surgery
Anti-Bacterial Agents
Blood Vessel Prosthesis
Rats
medicine.anatomical_structure
chemistry
Chemoprophylaxis
lipids (amino acids, peptides, and proteins)
Drug Therapy, Combination
Methicillin Resistance
Collagen
Rifampin
business
Subcutaneous tissue
Subjects
Details
- ISSN :
- 00224804
- Volume :
- 99
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of surgical research
- Accession number :
- edsair.doi.dedup.....b12410b3427175cc45422c3099df6bd5