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Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain
- Source :
- Obstetrics & Gynecology. 132:1386-1393
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- OBJECTIVE To study the association of prepregnancy body mass index (BMI) and gestational weight gain with child neurodevelopmental outcomes. METHODS We performed a secondary analysis of data from two parallel, multicenter, randomized, double-blind, placebo-controlled thyroxine replacement trials in pregnant women with either hypothyroxinemia or subclinical hypothyroidism who delivered at term. Body mass index was categorized as normal (18.5-24.9), overweight (25.0-29.9), or obese (30 or greater). We also evaluated early (20 weeks of gestation or less), late (greater than 20 weeks of gestation), and total gestational weight gain and categorized gestational weight gain as inadequate, adequate, and excessive per 2009 Institute of Medicine guidelines. Neurodevelopmental outcomes included 5-year Wechsler Preschool and Primary Scale of Intelligence and 3-year Differential Ability Scales-II. Linear and logistic regression analyses were performed and adjusted for maternal age, race-ethnicity, education, insurance status, parity, smoking and alcohol use, thyroid status (subclinical hypothyroidism or hypothyroxinemia), treatment group, gestational age at delivery, and neonatal sex. RESULTS Of the 948 women included, 380 (40%), 305 (32%), and 263 (28%) had normal, overweight, and obese prepregnancy BMI, respectively. A total of 106 (11%), 212 (22%), and 630 (66%) of women had inadequate, adequate, and excessive total rates of gestational weight gain, respectively. Maternal differences among the BMI categories included race-ethnicity, education, insurance type, parity, and thyroid status (all P
- Subjects :
- Adult
Male
medicine.medical_specialty
Ideal Body Weight
Overweight
Article
Body Mass Index
Young Adult
03 medical and health sciences
Child Development
0302 clinical medicine
030225 pediatrics
medicine
Humans
Obesity
030212 general & internal medicine
Randomized Controlled Trials as Topic
Subclinical infection
Wechsler Preschool and Primary Scale of Intelligence
Obstetrics
business.industry
Wechsler Scales
Obstetrics and Gynecology
Gestational age
Wechsler Adult Intelligence Scale
Gestational Weight Gain
Child, Preschool
Gestation
Female
medicine.symptom
business
Body mass index
Weight gain
Subjects
Details
- ISSN :
- 00297844
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Obstetrics & Gynecology
- Accession number :
- edsair.doi.dedup.....b11b2fbc8d75f8c1e9e10e20c386ac23