Back to Search
Start Over
Immunotherapy in colorectal cancer: is the long-awaited revolution finally happening?
- Source :
- Cancer Treatment and Research Communications, Vol 28, Iss, Pp 100442-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Immunotherapy has recently become a major treatment modality for several types of solid tumours, achieving remarkable and long-lasting remissions. In metastatic colorectal cancer patients (mCRC), immune checkpoint inhibitors (ICIs) were found to be effective as treatment for deficient mismatch repair (dMMR)/ microsatellite instability high (MSI-H) tumours and received regulatory approval for this indication. However, mCRC is a complex disease and dMMR/MSI-H tumours represent a minority of the cases; therefore, new strategies are needed to extend the benefits of immunotherapy to a larger population of patients. This review explores the immunological differences between dMMR/MSI-H and proficient mismatch repair (pMMR)/ microsatellite instability low (MSI-L) tumours, focuses on new proposed biomarkers to predict response to immunotherapy and illustrates results reported from the main clinical trials with immunotherapeutic agents in CRC, addressing the most promising approaches being currently developed.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Colorectal cancer
Immune checkpoint inhibitors
medicine.medical_treatment
Population
Complex disease
Internal medicine
medicine
Humans
education
RC254-282
education.field_of_study
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Microsatellite instability
Immunotherapy
medicine.disease
digestive system diseases
Clinical trial
Female
DNA mismatch repair
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 24682942
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Cancer Treatment and Research Communications
- Accession number :
- edsair.doi.dedup.....b118d06198a5672213614cc76e351e8d