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Successive cultures of mature hepatocytes for hepatocyte autotransplantation to assist liver function after liver resection for cancer
- Source :
- Oncology reports. 9(4)
- Publication Year :
- 2002
-
Abstract
- We developed a method for the rapid successive cultures of adult rat mature hepatocytes on plastic dishes while avoiding viral transformation or co-culture with other cell lines. This method also allows for culturing adult human mature hepatocytes up to the secondary culture. These can be expected to provide a good source for hepatocyte autotransplantation, and, combined with the previously reported methods for the transplantation of hepatocytes into the spleen, a promising option for the support of liver function after liver resection for cancer without the need for immunosuppressive agents.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Cell Transplantation
medicine.medical_treatment
Cell Culture Techniques
Mitosis
Spleen
Cell Separation
Biology
Transplantation, Autologous
Albumins
medicine
Animals
Humans
Microscopy, Phase-Contrast
Rats, Wistar
Cells, Cultured
Oncogene
Liver Neoplasms
Cancer
General Medicine
medicine.disease
Autotransplantation
Rats
Transplantation
medicine.anatomical_structure
Oncology
Liver
Cell culture
Hepatocyte
Hepatocytes
Liver function
Glycogen
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 1021335X
- Volume :
- 9
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Oncology reports
- Accession number :
- edsair.doi.dedup.....b10dc17247beec642f9a6a218fb2b6bb